Advil Extra Strength is a popular over-the-counter (OTC) pain reliever and fever reducer, manufactured by Pfizer. The active ingredient in Advil Extra Strength is ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking the production of prostaglandins, which are hormone-like substances that cause pain and inflammation in the body. Each tablet of Advil Extra Strength contains 250mg of ibuprofen, which is a higher dose than the regular strength version.
Pharmacology and Mechanism of Action
Ibuprofen, the active ingredient in Advil Extra Strength, is a potent inhibitor of cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins. By inhibiting these enzymes, ibuprofen reduces the production of prostaglandins, thereby reducing pain, inflammation, and fever. The mechanism of action of ibuprofen involves the inhibition of both COX-1 and COX-2 enzymes, although it has a slightly higher affinity for COX-2. This dual inhibition is responsible for the anti-inflammatory and analgesic effects of ibuprofen.
Indications and Uses
Advil Extra Strength is indicated for the temporary relief of headache, toothache, backache, menstrual cramps, and minor arthritis pain. It is also used to reduce fever and relieve pain associated with the common cold and flu. The extra strength formulation is designed to provide faster and more effective pain relief than the regular strength version.
| Active Ingredient | Dose | Indication |
|---|---|---|
| Ibuprofen | 250mg | Pain relief and fever reduction |
Side Effects and Interactions
Like all medications, Advil Extra Strength can cause side effects, including stomach upset, nausea, vomiting, dizziness, and headache. More severe side effects, such as stomach ulcers and bleeding, can occur with long-term use or in people with a history of stomach problems. Ibuprofen can also interact with other medications, such as blood thinners, diuretics, and lithium, which can increase the risk of adverse effects.
Contraindications and Warnings
Advil Extra Strength is contraindicated in people with a history of stomach ulcers or bleeding, as well as those with kidney disease or liver disease. It is also not recommended for people with aspirin-sensitive asthma or nasal polyps. Pregnant women should consult their doctor before taking Advil Extra Strength, as ibuprofen can increase the risk of premature closure of the ductus arteriosus in the fetus.
- Do not take Advil Extra Strength if you have a history of stomach ulcers or bleeding
- Consult your doctor before taking Advil Extra Strength if you have kidney disease or liver disease
- Avoid taking Advil Extra Strength with other NSAIDs or blood thinners
Can I take Advil Extra Strength with other medications?
+It is essential to consult your doctor or pharmacist before taking Advil Extra Strength with other medications, as ibuprofen can interact with certain medications, such as blood thinners, diuretics, and lithium. Your doctor or pharmacist can provide guidance on safe use and potential interactions.
How long can I take Advil Extra Strength?
+Advil Extra Strength is designed for short-term use, and you should not take it for more than 10 days unless directed by your doctor. Long-term use can increase the risk of adverse effects, such as stomach ulcers and bleeding.
In conclusion, Advil Extra Strength is a potent pain reliever and fever reducer that can provide effective relief for a variety of conditions, including headache, toothache, backache, and menstrual cramps. However, it is essential to follow the recommended dosage instructions and consult your doctor or pharmacist before taking Advil Extra Strength, especially if you have a history of stomach problems or are taking other medications.
